Mental health concerns are a growing global issue, with recent data indicating that nearly 1 in 8 individuals worldwide experience some form of emotional distress, including anxious feelings and mood fluctuations.1
Gastrointestinal Self-Tissue Response: Is the Microbiome to Blame?
Presented by: Nathan Morris, MD+
Gastrointestinal self-tissue response is often managed with immune modulation primarily focused on balancing cytokines. These interventions can be enormously helpful, but are we overlooking other critical underlying root causes? In this webinar, Dr. Nathan Morris will share his clinical experiences and effective strategies for addressing GI self-tissue response while exploring the critical role of the gut microbiome and its impact on immune system responses. This webinar challenges existing paradigms and promotes a deeper understanding of GI self-tissue response, encouraging participants to consider approaches that may enhance patient outcomes.‡
Learning Objectives:
Understand the underlying mechanism of GI self-tissue response and the immune system’s contributions.
Examine how the microbiome influences the immune system within the GI tract.
Explore how testing can guide strategies that address microbiome and immune system balance.
Discover interventions, including lifestyle changes and supplements that support immune system regulation in the GI tract.‡
About the Speaker
Nathan Morris, M.D.+, is the Chief Medical Advisor of Pure Encapsulations®. He resides in Colorado Springs, CO, where his multidisciplinary functional medicine practice, Good Medicine, focuses on making the complex simple. Dr. Morris is certified by the Institute for Functional Medicine and has practiced root cause medicine for over a decade. Dr. Morris is excited about the future of personalized medicine and its evolution as it empowers patients to understand their uniqueness and strengths.
+Dr. Morris is a retained advisor for Pure Encapsulations.
Mental health concerns are a growing global issue, with recent data indicating that nearly 1 in 8 individuals worldwide experience some form of emotional distress, including anxious feelings and mood fluctuations.1 Evidence suggests that disruptions in gut microbiota composition, often influenced by modern diets, stress and environmental exposures, may play a role in these rising mental health concerns.2
By leveraging dietary strategies, stress management techniques and targeted nutrient support, clinicians can provide natural, sustainable solutions that optimize the microbiota-gut-brain axis to address mental health and emotional resilience.
This blog explores the underlying mechanisms of the microbiota-gut-brain axis, its role in mood regulation and evidence-based strategies, including dietary interventions, stress management techniques and targeted nutrients such as probiotics, prebiotics, ashwagandha and L-theanine to support a balanced and resilient gut-brain connection.‡
What is the Microbiota-Gut-Brain Axis?
The microbiota-gut-brain axis is a bidirectional communication network between the gut microbiome, the central nervous system (CNS), autonomic nervous system (ANS), enteric nervous system (ENS) and the hypothalamus-pituitary-adrenal (HPA) axis.3,4 This intricate system regulates cognitive function, mood and overall mental well-being. The gut microbiome, composed of trillions of microorganisms, influences neurotransmitter production, immune modulation and hormonal balance, all affecting neurological function and mental & emotional health.4
The Microbiota's Influence on the Gut-Brain Axis
The microbiota-gut-brain axis functions through several key pathways facilitating communication between the gut microbiota and the brain. These include neural, immune and endocrine pathways, each playing a distinct role in supporting mental health.
Neural Pathway
The vagus nerve is a primary conduit between the gut and brain, transmitting signals directly from the gut microbiota to the central nervous system.3 Sometimes called the “sixth sense,” the vagus nerve can sense the microbiota and transfer the information to the nervous system, where it integrates and responds appropriately.5 Additionally, the enteric nervous system, often called the "second brain," contains millions of neurons that interact with gut microbes to regulate neurotransmitter production and brain activity.
Immune Pathway
The gut microbiome plays a critical role in immune system regulation, influencing cytokine regulation.3 Beneficial microbes promote the release of anti-inflammatory cytokines, such as interleukin-10 (IL-10). Non-beneficial microorganisms can trigger the production of cytokines, including interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α), which have been implicated in neuro-immune responses and mood disturbances.6
Endocrine Pathway
The endocrine pathway is more commonly referred to as the neuroendocrine system. The gut microbiota modulates gut hormones and neurotransmitters made in the gut and activates the hypothalamus-pituitary-adrenal (HPA) axis. The HPA axis governs the body's stress response and is involved in mood and immune function.3 Gut bacteria produce neurotransmitters such as serotonin, dopamine and GABA, which are essential for maintaining emotional stability.7
Image created in BioRender.com. Adapted from Góralczyk-Bińkowska A, et al. Int J Mol Sci. 2022 Sep 24;23(19):11245. doi: 10.3390/ijms231911245.
The Microbiota-Gut-Brain Axis and Mood
Studies suggest that gut microbiota imbalances are linked to mood fluctuations through altered neurotransmitter production, increased intestinal permeability, HPA dysregulation and heightened cytokine production. Specific bacterial strains, such as Bifidobacterium longum and Lactobacillus helveticus, have been shown to exert anxiolytic and mood-stabilizing effects by modulating gamma-aminobutyric acid (GABA), serotonin, dopamine, tryptophan, cortisol and cytokines.7
The Beneficial Influence of Specific Psychobiotic Strains
Adapted from: Ross K. Psychobiotics: Are they the future intervention for managing depression and anxiety? A literature review. Explore (NY). 2023;19(5):669-680. doi:10.1016/j.explore.2023.02.007
Beneficial Influence on:
Strains
Serotonin/Tryptophan Production
L. helveticus R0052 L. helveticus NS8 L. paracasei PS23 L. plantarum 299v B. infantis 35624
GABA Production
B. longum R0175 B. longum 1714 B. breve 1205
Cortisol Regulation
L. casei Shirota L. helveticus NS8 L. plantarum 299v B. longum 1714
Cytokine Balance
L. helveticus NS8 L. paracasei PS23
Nutrition and Lifestyle Interventions to Support the Microbiota-Gut-Brain Axis
Optimizing gut health through targeted nutrition and lifestyle interventions can strengthen the microbiota-gut-brain axis and improve mood regulation.
Diet and Its Influence on the Microbiome
Diet is described as one of the most influential and rapid contributors to microbial changes.3,4 A symbiotic relationship between fiber, polyphenols, prebiotics and fermented foods in the diet supports microbial diversity and enhances gut-brain communication.
Fiber is a food source for beneficial bacteria and promotes short-chain fatty acid (SCFA) production. Among its benefits, SCFAs support the GI barrier, promote the production of serotonin and GABA, modulate the immune system and influence the gut-brain connection through the vagus nerve.8 Fruits, vegetables, legumes and whole grains are rich sources of dietary fiber.
Polyphenol-rich foods like berries, apples, green tea, olive oil and dark chocolate may act as prebiotics.3 They have been shown to modulate the gut microbiome by increasing beneficial bacteria (i.e., Bifidobacterium, Firmicutes, Lactobacillus) and reducing harmful bacteria (i.e., Clostridium) while also supporting the body’s natural inflammatory processes and providing antioxidant and neuroprotective properties.9 Many polyphenol-rich foods are also a good source of fiber.
Prebiotics found in foods like garlic, onions, leeks, bananas, apples, honey, chicory root, flaxseed and asparagus fuel the growth of beneficial bacteria. By default, many prebiotic foods are also a source of fiber and polyphenols.
Fermented foods, including yogurt, kefir, kimchi, miso, cheese, vinegar and sauerkraut, provide beneficial probiotics that enhance gut microbiota composition and are a readily available source of SCFAs. Homemade fermented foods will provide the most probiotic diversity, and the fermentation process increases the polyphenol bioavailability.10
In contrast, a diet high in processed foods, refined sugars and artificial additives can disrupt the gut microbiome, contributing to mood fluctuations and an altered cytokine response.4
Stress, Physical Activity and Sleep: Their Influence on the Microbiome
Stress negatively impacts gut microbiota composition and vagal tone, increasing intestinal permeability and cytokine response.5 Conversely, gut microbiota diversity may influence how one handles stress, partially due to the influence on the production of GABA and serotonin.11 Stress management techniques like meditation, deep breathing and cognitive behavior therapy can help restore microbial balance, reduce HPA overactivity and support emotional resilience.5
Physical activity, particularly aerobic exercise, fosters microbial diversity and enhances the production of beneficial short-chain fatty acids (SCFAs), improving HPA axis control and positive moods.12
Sleep and the microbiome have a complementary relationship. Sleep is essential for maintaining a healthy microbiome, and a diverse microbiome has been positively correlated with increased sleep efficiency and total sleep time. Sleep deprivation has been linked to shifts in microbial composition and increased cortisol levels.13
Nutrient Solutions to Support the Microbiota-Gut-Brain Axis
Targeted supplementation with specific nutrients and bioactive compounds can further enhance the gut-brain connection and promote positive mental health.‡
Probiotics & Prebiotics
Probiotic supplementation has been extensively studied for its effects on gut health and mood regulation. More specifically, in 2013, the term 'psychobiotics' was coined, describing the beneficial bacteria that produce health benefits for mental health.7 Multiple probiotic strains have been shown to enhance GABA and serotonin receptor expression in the brain, reduce cortisol levels and reduce cytokine activation. (Table 1)‡
The most extensive and compelling evidence to support emotional and mental health exists for Lactobacillus helveticus Rosell-52 (RO052) and Bifidobacterium longum Rosell-175 (RO175).7 In a randomized, double-blind, placebo-controlled trial, supplementation with this combination maintained healthy urinary cortisol levels, indicating the potential to lessen occasional stress.14 In a separate analysis, supplemented subjects reported positive mood, relaxation and enhanced cognitive function.15 Further, multiple human studies have reported positive mood effects with this specific combination of probiotic strains.7
Image created in BioRender.com
Prebiotics works synergistically with probiotics. The various types of prebiotics include fructans, galactooligosaccharides, xylo-oligosaccharides, chitooligosaccharides, lactulose, resistant starch and polyphenols. Prebiotics modulate and support the growth of the gut microbiota, specifically Bifidobacteria and Lactobacilli, increase SFCA production, improve gut barrier function, modulate the immune system and positively influence mood.16‡
Butyrate
Butyrate is one of the three most abundant short chain fatty acids (SCFAs) produced by anaerobic bacterial fermentation of polysaccharides/fiber in the colon, where it serves as an energy source for epithelial cells.17 Considered a functionally versatile molecule, butyrate provides support for maintaining gastrointestinal health and regulating the neuro-endocrine-immune pathways, in part due to its ability to cross the blood-brain barrier.17,18‡
Ashwagandha
Ashwagandha (Withania somnifera) is an adaptogenic herb that modulates the HPA axis and maintains healthy cortisol levels. In a double-blind trial, 60 participants with high perceived stress scores were randomized to receive KSM-66 Ashwagandha® extract (125 mg or 300 mg) or placebo twice daily for 8 weeks. A significant reduction in perceived stress scale (PSS) scores was observed with both doses of ashwagandha compared to the placebo group. Mean cortisol response decreased by 17% and 33% in the groups receiving 125 mg and 300 mg twice daily, respectively, after 8 weeks. Subjects receiving ashwagandha also exhibited significant improvements in sleep quality.19‡
L-Theanine
L-theanine an amino acid found in green tea, may be most recognized for its ability to exert anxiolytic effects by modulating GABA activity and for its role in regulating the stress response. In a double-blind crossover trial, 30 healthy adults received l-theanine (200 mg Suntheanine®/day) or placebo for 4 weeks. L-theanine significantly improved stress-related symptoms, including low-mood symptoms and occasional anxiety per validated questionnaires and sleep (Pittsburgh Sleep Quality Index; PSQI)‡
Newer research also suggests that l-theanine influences the gut-brain connection by increasing beneficial bacteria, such as Lactobacillus, while also decreasing non-beneficial bacteria, such as Closterium.21
Pure Encapsulations® Nutrient Solutions
Pure Encapsulations provides uniquely formulated products made with high-quality, pure ingredients backed by verifiable science to complement your plan of care and support microbiota-gut-brain axis in your patients.‡
ProbioMood is a clinically researched combination of probiotic strains that promotes emotional well-being and relaxation. This formula contains the well-researched strains Lactobacillus helveticus Rosell-52 and Bifidobacterium longum Rosell-175. It was developed using an innovative, patented microencapsulation process designed to protect the probiotic strains from harsh conditions, including gastric acidity.‡
Suggested Use: Take one (1) capsule daily, with or between meals
Poly-Prebiotic is a shelf-stable prebiotic formula that includes 1.5 g of clinically researched PreticX™ XOS (xylo-oligosaccharides) that enhances the growth of Bifidobacteria. In contrast to FOS and other common prebiotics, studies on XOS report very low incidence of gas and bloating.20,21
Suggested Use: Take three (3) capsules, 1-2 times daily, with or between meals
SunButyrate™-TG liquid is a unique butyrate-rich triglyceride oil that allows for direct delivery of 875 mg of butyric acid (per serving) to the intestines. Benefits include supporting gut cell and barrier function and promoting cytokine balance.‡
Suggested Use: As a dietary supplement, take 1 teaspoon, 1-3 times daily, with meals.
Daily Calm combines GABA with clinically backed saffron (affron®), ashwagandha (KSM-66®) and l-theanine (Suntheanine®) to relieve feelings of occasional stress and anxiety. Together, these ingredients address common mental health needs while supporting mood and sleep quality with continued use.‡
Suggested Use: Take one (1) capsule, two times daily between meals
Conclusion
The microbiota-gut-brain axis plays a pivotal role in supporting mental health. The gut microbiota communicates with the brain through neural, immune and endocrine pathways, influencing neurotransmitter production, stress response and cytokine regulation. Healthcare professionals can support gut health and enhance mental well-being by utilizing targeted nutrients such as probiotics, prebiotics, ashwagandha and l-theanine, in combination with diet and lifestyle strategies.
Resources
Microbiota-Gut-Brain Axis Protocol: Designed by our scientific and medical advisors to help you deliver the most effective care and support for your patient's intestinal health.
Drug-Nutrient Interaction Checker: Provides valuable information on potential interactions between your patients' prescriptions, over-the-counter medications and nutritional supplements.
PureInsight™: Our streamlined platform easily collects patient data and provides valuable recommendations to help achieve their health goals.
Virtual Dispensary: Our Pure Patient Direct program provides account holders FREE access to our virtual dispensary to help simplify patient sales and reduce in-office inventory.
An Integrative Approach to Modulating Self-Tissue Response in Joints
Presented by: Felice Gersh, MD+
Self-tissue response in joints affects 1 in 200 adults globally, predominantly women.1,2 This condition mainly targets joints, but can also impact other organs, which has the potential to impact quality of life. Early intervention can often make integrative methods the main approach for self-tissue response in joints.
While conventional therapies offer new management possibilities, they are most effective when combined with integrative modalities.
This presentation will cover key manifestations, clinical markers and drivers of self-tissue response, offering integrative strategies to manage the condition while improving quality of life and health span.
Join us to learn how to implement effective integrative approaches for self-tissue response in joints and improve patient outcomes.
Learning Objectives:
Recognize the key manifestations, contributing factors, and systemic impacts of self-tissue
response in joints.
Discuss conventional therapeutic management of self-tissue response in joints.
Review a comprehensive, integrative approach for managing self-tissue response in joints
to help improve patient outcomes.
About the Speaker
Felice L. Gersh, M.D.+, is an award-winning physician, board-certified in both OB/GYN and Integrative Medicine. She has special expertise in the use of female hormones, the impact of environmental toxicants on metabolic and reproductive functions and on all aspects of lifestyle medicine. She graduated from Princeton University and the University of Southern California School of Medicine. She completed her OB/GYN residency at Kaiser Hospital in Los Angeles and was fellowship-trained in integrative medicine at the University of Arizona School of Medicine. Dr. Gersh is the Medical Director of the Integrative Medical Group of Irvine and helped co-develop the PureWoman™ exclusive.
+Dr. Gersh is a retained advisor for Pure Encapsulations.
1Silman AJ, Pearson JE. Arthritis Res. 2002;4 (Suppl 3):S265-S272 2Shah B, American College of Rheumatology Committee on Communications and Marketing. Updated February 2023.
Autophagy vs. Inflammasome Assembly: A Key Leverage Point in Functional Medicine Cases
Presented by: Sam Yanuck, DC+
Autophagy is the process by which cells repair themselves. Bone marrow stem cells depend on it, as do all white blood cell types and brain cells. Many patients have altered autophagy, and for most of them, it’s a key reason they don’t improve. Inflammasome assembly generates cytokines that alter autophagy. In this webinar, functional immunology thought leader, Dr. Sam Yanuck, will teach you to recognize and address altered autophagy and its impact on metabolism, immunology, thyroid function, energy, cognition and a host of other clinical factors you see in practice every day.
You’ll come away with knowledge of the following key objectives:
Understand autophagy and its impact on mitochondrial and thyroid function, self-tissue response and other crucial determinants of health.
Understand the mechanisms by which autophagy becomes altered and how to identify factors in a case that contribute to those changes.
Understand the clinical approach to supporting autophagy and how that approach fits into the broader picture of case management.
About the Speaker
Samuel F. Yanuck, DC+, is the CEO and Director of Education for Cogence®, an online functional immunology course, serving nearly 10,000 clinician participants from more than 60 countries around the world. He is an adjunct assistant professor in the Program on Integrative Medicine at the University of North Carolina School of Medicine. Dr. Yanuck co-directs the Yanuck Center for Life and Health, a functional medicine clinic in Chapel Hill, North Carolina, where he’s been seeing patients from everywhere since 1992. Dr. Yanuck helped co-develop the PureResponse™.
+Dr. Yanuck is retained advisor to Pure Encapsulations.
The intestinal barrier is more than just a digestive checkpoint - it's a key defender against non-beneficial microorganisms, toxins, and antigens while allowing the body to absorb vital nutrients. When this barrier is compromised, it can lead to a cascade of symptoms, including occasional bloating, abdominal discomfort, irregular bowel movements, and nutrient malabsorption.
One common consequence of a weakened barrier includes intestinal concerns, often triggered by self-tissue response. According to the CDC, over 3.1 million Americans experience intestinal immune concerns,1 which can disrupt nutrient absorption and weaken overall immunity.
This article will explore the essential nutrients that support the mucosal immune system and strengthen the intestinal barrier, offering insights into how dietary interventions can help maintain gut integrity and overall health.
A Healthy Barrier and Its Functions
The intestinal barrier consists of a monolayer of specialized epithelial cells that line the gut lumen, forming a selectively permeable barrier. These epithelial cells are sealed together by tight junction proteins, including occludin, claudin-1, and zonula occludens-1 (ZO-1).2,3 Tight junctions function as "gatekeepers," determining what substances can pass through the intestinal lining into the bloodstream while preventing the entry of harmful microorganisms, toxins, and antigens.
The intestinal barrier also includes a mucus layer, which provides physical protection by preventing direct contact between microbes and the epithelial cells. It contains antimicrobial peptides and secretory immunoglobulin A (sIgA), which neutralize non-beneficial microorganisms and contribute to immune defense. This layer is rich in immune cells such as macrophages, dendritic cells, and T-cells, which play key roles in maintaining immune homeostasis.3
The primary functions of the gut barrier include:4
absorption of nutrients
regulation of immune responses
maintenance of intestinal homeostasis
prevention of the translocation of harmful substances
supporting bidirectional communication between the gut microbiota and the immune system
Created in BioRender.com
A Compromised Barrier
When the integrity of the gut barrier is compromised, it can lead to increased intestinal permeability, commonly called "leaky gut." Increased permeability allows larger molecules, such as undigested food particles, toxins, and microbes, to enter the bloodstream, potentially triggering an unbalanced state and immune activation. This, in turn, can lead to persistent intestinal distress and self-tissue response in the intestines, further exacerbating symptoms and contributing to systemic changes.
Factors That Impact GI Integrity and Lead to a Self-Tissue Response
The integrity of the intestinal barrier and the development of a self-tissue response in the intestines is rarely a result of one factor. Instead, it is a multifactorial process influenced by numerous factors, including the health of the microbiome, immune and cytokine responses, and nutrition, lifestyle, and health components.
The Health of the Microbiome
The gut microbiome is a complex ecosystem of nearly 100 trillion microorganisms that maintain mucosal health.2 Beneficial microbes such as Bifidobacteria, Lactobacilli, enterococcus, and Clostridium produce short-chain fatty acids (SCFAs), which support tight junction integrity and signaling.2
Conversely, a microbial imbalance resulting from low microbial diversity or gastrointestinal infections can increase intestinal permeability and promote an increased immune response. Evidence suggests that individuals with a self-tissue response in the intestines have a reduction of beneficial bacterial species in the gastrointestinal tract.5
The Immune and Cytokine Responses in the Gut
The gut-associated lymphoid tissue (GALT) is an integral part of the immune system, responsible for responding to non-beneficial bacteria while maintaining tolerance to dietary antigens and commensal bacteria. Cytokines such as interleukin-10 (IL-10) promote immune tolerance, whereas excessive production of cytokines like IL-6 and TNF-α disrupt mucosal balance. Activation of these cytokines can perpetuate barrier and tissue changes, contributing to systemic immune activation.6,7
Nutrition, Lifestyle & Health Components
Nutrition: The Standard American Diet (Western Diet) contains a high intake of refined sugars, processed carbohydrates, red or processed meat, omega-6 fatty acids, and alcohol, exacerbating the body's cytokine balance processes. The way of eating is also partially responsible for decreased bacterial diversity in the gut and contributes to inadequate intake of essential vitamins and minerals. Poor nutrient absorption is a common presentation for people with a self-tissue response in the intestines.8,9
Conversely, a diet rich in fruits and vegetables, fiber, omega-3 fatty acids, fish, grains, and legumes protects and supports a healthy GI barrier. Studies have shown that eliminating some food groups, such as gluten and dairy or other known food allergies or intolerances, may help reduce GI symptoms and support a self-tissue response.9 Special attention should be given to replacing vitamins and minerals, such as B vitamins, vitamin D, electrolytes, and omega-3 fatty acids, as indicated.10
Lifestyle: Perceived stress that is uncontrolled or not well managed is considered a predictor of the exacerbation of GI symptoms and self-tissue response.11 Poor sleep quality is associated with elevated levels of IL-6, TNF-α, nuclear factor-kB (NF-kB), and CRP (C-reactive protein), known markers of the immune system.12
Health Components: General health components such as a history of intake of medications, exposure to environmental toxins and genetic predisposition also play a role in the susceptibility to a compromised intestinal barrier and immune response.
Nutrient Solutions to Build the Intestinal Barrier
Glutamine is the most abundant amino acid in the body. It is the primary energy source for enterocytes (the cells that line the small intestine and colon), utilizing about 30% of total glutamine.13,14 It also helps maintain healthy intestinal integrity by enhancing the intestine's protective mucosal lining and promotes tissue repair from metabolic stress.14‡
Studies have demonstrated that L-glutamine supplementation reduces intestinal permeability and supports outcomes in patients with compromised barrier integrity.13‡
Arabinogalactan, a fiber derived from larch trees, is a prebiotic that promotes the growth of beneficial gut bacteria. such as Bacteroidetes, Bifidobacterium, and Faecalibacterium praisnitzii, which are crucial for proper gut-associated lymphoid tissue (GALT) function and development.15 These bacteria produce SCFAs, including butyrate, which enhance epithelial integrity and modulate cytokine production.‡
Arabinogalactan also has immunomodulatory properties, supporting the production of natural killer (NK) cells and promoting mucosal immunity.16 It may also promote healthy production of cytokines, which mediate cell-to-cell communication between cells involved in the immune response. Its dual role as a prebiotic and immune supporter makes it a valuable addition to protocols to restore gut health.‡
Perilla (Perilla frutescens) is a traditional herb rich in polyphenols and rosmarinic acid. which promote cytokine balance and antioxidant effects. Its active compounds reduce the production of cytokines such as IL-6 and TNF-α, which are implicated in intestinal immune changes.17‡
In a randomized, controlled trial involving 50 individuals, 150 mg of Benegut®Perilla frutescens extract twice daily offered significant support for GI comfort.18 Perilla also stabilizes mast cells, reducing hypersensitivity reactions that can contribute to mucosal damage.19‡
Additionally, its antioxidant properties help neutralize reactive oxygen species (ROS), protecting the intestinal lining from oxidative stress.20
Astragalus (Astragalus membranaceus) is a well-known adaptogenic herb with a long history of use in Traditional Chinese Medicine (TCM). It promotes immunity by supporting B and T lymphocyte production, balancing Th1/Th2, and modulating cytokine response.21 It also protects the intestinal barrier by upregulating tight junction proteins and secretory IgA (sIgA) production. This key immune component coats the intestinal lining and prevents the adherence of non-beneficial microorganisms.22 Its adaptogenic properties further support resilience against stress, a contributing factor to a compromised intestinal barrier.23‡
Deglycyrrhizinated licorice (DGL) supports the healing of the GI barrier and other mucous membranes by increasing blood supply to mucosa, increasing the production of mucus, which acts as a protective barrier for the intestinal lining and improves the life span of intestinal cells.24‡
Created in BioRender.com
Pure Encapsulations® Nutrient Solutions
Pure Encapsulations offers expertly crafted supplements made with high-quality, pure ingredients and supported by verifiable scientific research. These products are designed to complement personalized care plans.‡
Epi-Integrity powder: is a carefully formulated blend of glutamine, prebiotic fiber, and herbal extracts that support the modulation of mucosal immune responses and promote gastrointestinal (G.I.) barrier integrity. It helps maintain a balanced microbiome, provides mucosal protection, and supports epithelial cell health for optimal gut function.‡
Suggested Use: 1 scoop, 1-2 times daily. Add 1 serving to 8 oz of water or juice. Shake or stir until dissolved.
Conclusion
Restoring intestinal barrier integrity and supporting mucosal immune responses are essential for addressing symptoms associated with self-tissue responses in the gut. Healthcare providers can leverage evidence-based nutritional strategies to address the underlying factors contributing to a compromised barrier. Nutrients such as L-glutamine, arabinogalactan, perilla, Astragalus, and DGL offer targeted support for mucosal repair, cytokine modulation and immune balance.‡
Resources
Gastrointestinal Self-Tissue Response Protocol: Designed by our scientific and medical advisors to help you deliver the most effective care and support for your patient's intestinal health.‡
Drug-Nutrient Interaction Checker: Provides valuable information on potential interactions between your patients' prescriptions, over-the-counter medications and nutritional supplements.
PureInsight™: Our streamlined platform easily collects patient data and provides valuable recommendations to help achieve their health goals.
Virtual Dispensary: Our Pure Patient Direct program provides account holders FREE access to our virtual dispensary to help simplify patient sales and reduce in-office inventory.
Self-Tissue Response: Managing the Case from Start to Success
Presented by: Sam Yanuck, DC+
Clinical success depends on your ability to recognize patterns in the case, address those patterns, observe results and repeat that cycle. Success also depends on your ability to partner with the patient and actively involve them in that process. In this webinar, functional immunology thought leader, Dr. Sam Yanuck, will walk you through a functional immunology case and provide real clinical examples that illustrate the order of operation of care for self-tissue response, how to manage key pivot points in the case, and how to communicate with the patient effectively at key moments.
You’ll come away with knowledge of the following key objectives:
How to identify key opportunities in the case and apply clinical leverage to maximize your chance of success.
How to move the patient through the stages of their case. Creating alliance, communicating proper expectations, and giving the patient the image of the flow of the case, so you are partners in the process.
How digestion and microbial balance in the GI tract drive self-tissue response, brain fog and fatigue.
About the Speaker
Samuel F. Yanuck, DC+, is the CEO and Director of Education for Cogence®, an online functional immunology course, serving nearly 10,000 clinician participants from more than 60 countries around the world. He is an adjunct assistant professor in the Program on Integrative Medicine at the University of North Carolina School of Medicine. Dr. Yanuck co-directs the Yanuck Center for Life and Health, a functional medicine clinic in Chapel Hill, North Carolina, where he’s been seeing patients from everywhere since 1992. Dr. Yanuck helped co-develop PureResponse™.
+Dr. Yanuck is retained advisor to Pure Encapsulations.
