Self-Tissue Response: Core Immunology and Clinical Strategies

Presented by: Sam Yanuck, DC⁺

Increasing your knowledge of functional immunology can give you a valuable advantage in your practice because much of what is seen in functional medicine practice has an immunological basis. This is especially true in cases involving self-tissue response, where the presence of other common factors like GI function, autonomic function, metabolism, food responses and environmental factors can all play a role. This webinar will explore the underlying immunology of self-tissue response, describe connections to other factors common in these cases and present interventions that can support the immunological health of your patients.

You’ll come away with knowledge of the following key objectives:

• Review the immunological mechanisms that underly all self-tissue response.
• Learn to see complex cases as a map of the patient’s immunological factors.
• Recognize the connections between the immune system and the larger functional medicine picture.
• Identify and address key immunological leverage points to support the health and well- being of your patients.

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James M. Greenblatt, MD, is a pioneer in the field of integrative medicine and has treated patients since 1988. He was the Chief Medical Officer at Walden Behavioral Care in Waltham, MA for 21 years and is an Assistant Clinical Professor of Psychiatry at Tufts University School of Medicine and Dartmouth College Geisel School of Medicine. An acknowledged integrative medicine expert, Dr. Greenblatt regularly lectures on the scientific evidence for nutritional interventions in psychiatry, has authored eight books, and is the founder of Psychiatry Redefined, an educational platform dedicated to the personalized, evidence-based treatment of mental health. Dr. Greenblatt helped co-develop the PureSYNAPSE™ exclusive.  

^{+Dr. Greenblatt is a paid advisor for Pure Encapsulations.} 

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Kate Kresge, ND, is the Head of Medical Education at Rupa Health's Rupa University and Host of the Root Cause Medicine Podcast. She has advanced training in mind-body medicine and functional medicine approaches in mental health. Before joining Rupa, Dr. Kate was the founding Director of Functional Medicine at Sanare Today, a multi-location practice on the east coast of the U.S. that combines therapy, coaching, natural medicine and more to help people thrive. She is passionate about democratizing access to good medicine through low-cost interventions like nutrients, mindfulness and more. 

Kelly C. Heim, PhD, is a Senior Consultant of Medical Affairs at Pure Encapsulations® and Founder and Senior Science Editor at Integrative Pharmacology. He received his doctoral degree in pharmacology from Geisel School of Medicine at Dartmouth College and specializes in the pharmacology of natural compounds. Dr. Heim is a published author and illustrator of various studies, scholarly reviews and book chapters. He offers complementary learning resources on the basics of clinical pharmacology of natural products via his website, IntegrativePharmacology.com

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Samuel F. Yanuck is the CEO and Director of Education for CogenceImmunology.com, an online functional immunology course, serving nearly 10,000 clinician participants from more than 60 countries around the world. He is an adjunct assistant professor of Integrative Medicine, in the Department of Physical Medicine and Rehabilitation at the University of North Carolina School of Medicine. Dr. Yanuck co-directs the Yanuck Center for Life and Health, a functional medicine clinic in Chapel Hill, North Carolina, where he’s been seeing patients from everywhere since 1992. Dr. Yanuck helped co-develop the PureResponse™ exclusive.   

+Dr. Yanuck is a paid advisor for Pure Encapsulations.  

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Felice L. Gersh, M.D. is an award-winning physician, board-certified in both OB/GYN and Integrative Medicine. She has special expertise in the use of female hormones, the impact of environmental toxicants on metabolic and reproductive functions and on all aspects of lifestyle medicine. She graduated from Princeton University and the University of Southern California School of Medicine. She completed her OB/GYN residency at Kaiser Hospital in Los Angeles and was fellowship-trained in integrative medicine at the University of Arizona School of Medicine.  

+Dr. Gersh is a paid advisor for Pure Encapsulations.

‡This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

1. Santoro N. J Womens Health (Larchmt). 2016 Apr;25(4):332-9. 

The Root Cause of Common Acne: The Gut-Skin Connection

Presented by: Julie Greenberg, ND⁺

While acne is traditionally thought to affect teens, adult acne is on the rise and affects as many as 40% of adult women. In this webinar, Dr. Greenberg will present the latest research on the gut-skin connection and describe the specific patterns she sees in the gut microbiota of patients with common acne. She’ll share impactful case studies along with before and after photos to illustrate how addressing the gut microbiome can lead to the clearance of common acne.

Register to learn:

• About the underlying causes of common acne


• The roles the mTOR pathway and Fox01 play in the development of common acne


• How gut microbes contribute to underlying mechanisms


• How to utilize stool tests and organic acid tests to identify the root cause(s) of common acne

Thyroid and the Female Patient: An Integrative Approach to Thyroid Health

Presented by: Angela D. Mazza, DO, ABAARM, FAAMFM, ECNU⁺

Thyroid health is a concern for an estimated 11.7% of Americans.¹ Women are much more likely to be affected than men. In this webinar, thyroid specialist Dr. Angela Mazza will explore the uniqueness of the female patient, describe underlying factors that influence thyroid health, and provide integrative solutions for maintaining healthy thyroid hormones.

1. Wyne KL, Nair L, Schneiderman CP, et al. J Endocr Soc. 2022 Nov 10;7(1):bvac172. doi: 10.1210/jendso/bvac172.

Learning objectives:

• Review the basic physiology of thyroid hormone production and action.


• Present the critical micronutrients needed for optimal thyroid function.^‡


• Discuss the uniqueness of the female patient.


• Offer integrative approaches to maintaining thyroid hormone balance

Premenstrual Syndrome (PMS): Connecting the dots for a healthy menstrual cycle

Presented by: Amy Doyle, MS, CNS⁺

Premenstrual Syndrome (PMS) impacts the daily functioning of approximately 30% of cycling women. In this webinar, Board Certified Nutrition Specialist Amy Doyle will identify the different hormone patterns associated with PMS and review the interactions between the Hypothalamic-Pituitary-Adrenal-Thyroid and Gonadal axes. A multi-modal approach that includes dietary and lifestyle interventions and the beneficial use of targeted nutritional supplements to address PMS will be presented.

Learning objectives:

• Summarize the regular hormone fluctuations during the menstrual cycle and patterns associated with PMS.


• Recognize the interactions between the Hypothalamic-Pituitary Adrenal (HPA) axis, the Hypothalamic-Pituitary Thyroid (HPT) axis and the Hypothalamic-Pituitary-Gonadal (HPG) axis as they relate to premenstrual symptoms.


• Understand the roles the gut microbiome, immune system, insulin and weight play in PMS.


• Review dietary, lifestyle and supplement interventions that can support the physical and emotional symptoms of PMS

Intestinal Permeability: Evidence-Based Approaches to Supporting Gut Barrier Function

Presented by: Kelly Heim, Ph.D.⁺

Intestinal barrier hyperpermeability ("leaky gut") is a common and often overlooked feature of gastrointestinal, immunological and metabolic health. The integrity of the gut barrier is influenced by health status, dietary composition, medications, microbiota and diverse lifestyle factors. Despite over 50 years of research and thousands of scholarly publications on intestinal permeability, clinical approaches are subject to guesswork and trial and error. This webinar will distill the current clinical evidence and provide practical, evidence-based strategies to support and maintain a healthy gut barrier.

Learning objectives:

• Define "leaky gut" and its underlying causes


• Recognize the systemic impact of gut barrier integrity on metabolic, immune and mental health


• Describe simple dietary and lifestyle-based interventions that enhance or maintain intestinal barrier integrity


• Review current evidence-based modalities and condition-specific interventions that support and maintain gut barrier integrity