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Memory & Mood

Blog

Immunomodulation for Mental Health: A Focus on Positive Mood

  • Nov 26, 2024
Pure Encapsulations Pro Blog
Discover the link between immune health and mood regulation. Learn how immunomodulation could offer new hope for those experiencing low mood.

Immunomodulation for Mental Health: A Focus on Positive Mood

By: Kim Ross, DCN, CNS, LDN, IFMCP

Introduction 

Positive mood and emotional well-being are essential to overall health, yet low mood affects a significant portion of the global population. According to the World Health Organization, 5% of adults (over 280 million people) worldwide experience some level of low mood or loss of pleasure and interest in activities. In comparison, it is estimated to affect about 10% of all adults in the United States.1,2 Additionally, it is reported that low moods are 50% more common in women than men.2  

People struggling with low mood experience variable ranges of psychological and physical symptoms. These can include pervasive feelings of sadness or hopelessness, a lack of interest in activities, fatigue and difficulty concentrating. These symptoms are often accompanied by physical manifestations such as changes in appetite, sleep disturbances and decreased energy levels.2 Importantly, underlying immunological processes have been found to play a critical role in regulating mood states, opening avenues for innovative therapeutic approaches.1

Immunological Basis of Mood and Mental Health

Immune System Activation and the Brain

An area of science called neuroimmunology has highlighted the deep, bidirectional connection and communication between the brain and immune system and its influence on mood regulation.3–5 Immune cells, including microglia, astrocytes and cytokines, interact directly with neurons, contributing to the modulation of mood and cognitive function.6,7

Studies suggest that systemic immune activation can affect the nervous system via production of cytokines, including  interleukin-1 beta (IL-1b), interleukin-6 (IL-6), interleukin-8 (IL-8) and tumor necrosis factor-alpha (TNF-α), which can cross the blood-brain barrier.1 Alteration of the immune/brain interaction can affect neurotransmitter balance, affecting the production of serotonin, GABA, dopamine and norepinephrine, which are critical for mood stabilization.4

Image created with BioRender®.Image created with BioRender®.

Cytokines and Neurotransmitter Balance

Cytokines can influence neurotransmitter balance by modulating key pathways responsible for serotonin, dopamine and glutamate/GABA synthesis and reuptake. For example, the cytokine interferon-gamma (IFN-g) can activate the enzyme indoleamine 2,3-dioxygenase (IDO), which degrades tryptophan, a precursor to serotonin, into kynurenine. This shift reduces serotonin availability, affecting mood regulation.8 However, some kynurenine metabolites have neuroprotective properties, reinforcing the importance of having a healthy cytokine balance within the body.8

Similarly, some cytokines (IL-1b, IL-6, IFN-g, and TNF-α) have been shown to decrease the transport of tyrosine (a non-essential amino acid produced from phenylalanine), which is needed for the synthesis of dopamine and catecholamines.9  Cytokines have also been implicated in increasing glutamate activity through quinolinic acid production.10

Lifestyle Components to Support Positive Mood Through Cytokine Modulation

Nutrition: Diet plays a critical role in immune and mood regulation. A nutrient and polyphenol-dense Mediterranean diet is rich in vegetables, fruits, omega-3 fatty acids and fiber. It has been shown to modulate cytokine levels and promote mental well-being.11,12 

Exercise: Regular, moderate-intensity physical activity has been shown to promote cytokine balance. Exercise also helps to reduce stress and provides neuroprotection through the antioxidant system.13

Sleep: Poor sleep quality is associated with elevated levels of IL-6, TNF-α, nuclear factor-kB (NF-kB), and CRP (C-reactive protein), important markers of the immune system.14 Prioritizing sleep hygiene and achieving 7 to 9 hours of restorative sleep can help restore immune balance and positively influence mood.

Mind-Body Practices: Yoga, meditation and mindfulness practices can reduce stress, improve sleep and promote a balanced immune response, including the modulation of cytokines.15

Nutrient Solutions to Support a Positive Mood Through Cytokine Modulation

Polyphenols, including flavonoids, curcumin, epigallocatechin gallate (EGCG) and oligomeric proanthocyanidins (OPCs), are found in a variety of plant-based foods, such as vegetables, berries, green tea and dark chocolate.16

Curcumin, the active compound in turmeric, exerts its mood benefits by regulating cytokine activity, mainly by reducing levels of TNF-α and IL-6. By maintaining a healthy cytokine response, curcumin supports neurotransmitter balance, especially the monoamines, serotonin, norepinephrine and dopamine.17 Further, preclinical data suggest that curcumin may bind to NMDA receptors to balance glutamate/GABA signaling.18‡

Green tea extract contains a high concentration of EGCG, a compound known for its antioxidant and cytokine-modulating properties. The catechins in green tea also help boost dopamine levels, while theanine modulates glutamate, GABA, serotonin and dopamine levels, enhancing a sense of calm and providing cytokine balance.19,20 Green tea extract also supports neurogenesis and promotes the release of brain-derived neurotrophic factor (BDNF), which plays a critical role in mood regulation.19‡

Pycnogenol, derived from the bark of the French maritime pine tree, is another potent immunomodulator that shows promising cognitive-enhancing effects by reducing oxidative stress and enhancing neurotransmitter activity.21 Over 450 articles have been published highlighting the plethora of benefits of this compound in multiple areas of health.22‡

Pure Encapsulations® Nutrient Solutions

Pure Encapsulations® provides uniquely formulated products made with high-quality, pure ingredients backed by verifiable science to complement your plan of care and support healthy aging in your patients.‡

CurcumaSorb Mind offers support for mental alertness, relaxation and occasional stress. Promotes emotional wellness by supporting healthy levels of serotonin and dopamine.‡

Suggested Use: Take 2 capsules, 1-2 times daily, with meals.  

Pycnogenol® 100 mg supports cognitive function and cardiovascular health‡

Suggested Use: Take 1 capsule, 1-2 times daily, with or between meals.

Green Tea extract (decaffeinated) supports neurocognitive, cardiovascular and cellular health. Provides optimal cellular function and antioxidant protection‡

Suggested Use: Take 1 capsule, 1-4 times daily, with meals.

Conclusion

The intricate relationship between the immune system and mood highlights the importance of cytokine modulation in mental health. By targeting key cytokines involved in mood regulation, it is possible to influence neurotransmitter pathways and foster positive emotional states.  Making lifestyle changes and using immune-modulating ingredients like pycnogenol and polyphenols offers a holistic approach to supporting mental well-being.

Resources

Positive Mood Protocol‡: Designed by our clinician partners to help you deliver the most effective care and support for your patient's mood.

Drug-Nutrient Interaction Checker:  Provides valuable information on potential interactions between your patients' prescriptions, over-the-counter medications and nutritional supplements.

PureInsight™: Our streamlined platform easily collects patient data and provides valuable recommendations to help achieve their health goals.

Virtual Dispensary: Our Pure Patient Direct program provides account holders FREE access to our virtual dispensary to help simplify patient sales and reduce in-office inventory.

You can also explore Pure Encapsulations® to find On-Demand Learning, Clinical Protocols and other resources developed with our medical and scientific advisors.

References

  1. Miller AH, Raison CL. Nat Rev Immunol. 2016;16(1). doi:10.1038/nri.2015.5
  2. World Health Organization (WHO). Accessed June 29, 2024. https://www.who.int/news-room/fact-sheets/detail/depression
  3. Zhou L, Foster JA. Neuropsychiatr Dis Treat. Published online 2015. doi:10.2147/NDT.S61997
  4. Ross K. Explore. Published online 2023. doi:10.1016/j.explore.2023.02.007
  5. Nutma E, Willison H, Martino G, Amor S. Clin Exp Immunol. 2019;197(3). doi:10.1111/cei.13279
  6. Dantzer R.  Physiol Rev. 2018;98(1). doi:10.1152/physrev.00039.2016
  7. Daëron M. Front Immunol. 2022;13. doi:10.3389/fimmu.2022.984678
  8. Tsuji A, Ikeda Y, Yoshikawa S, et al.  Int J Mol Sci. 2023;24(6). doi:10.3390/ijms24065742
  9. Mancini M, Natoli S, Gardoni F, Di Luca M, Pisani A.  Int J Mol Sci. 2023;24(6). doi:10.3390/ijms24065618
  10. Ho TC, Teresi GI, Segarra JR, et al.  Front Psychiatry. 2021;12. doi:10.3389/fpsyt.2021.642976
  11. Koelman L, Egea Rodrigues C, Aleksandrova K. Advances in Nutrition. 2022;13(1). doi:10.1093/advances/nmab086
  12. Ventriglio A, Sancassiani F, Contu MP, et al. Clinical Practice & Epidemiology in Mental Health. Published online 2020. doi:10.2174/1745017902016010156
  13. Docherty S, Harley R, McAuley JJ, et al. BMC Sports Sci Med Rehabil. 2022;14(1). doi:10.1186/s13102-022-00397-2
  14. Irwin MR, Opp MR. Neuropsychopharmacology. 2017;42(1). doi:10.1038/npp.2016.148
  15. Black DS, Slavich GM. Ann N Y Acad Sci. 2016;1373(1). doi:10.1111/nyas.12998
  16. Winiarska-Mieczan A, Kwiecień M, Jachimowicz-Rogowska K, Donaldson J, Tomaszewska E, Baranowska-Wójcik E. Int J Mol Sci. 2023;24(3). doi:10.3390/ijms24032258
  17. Peng Y, Ao M, Dong B, et al. Drug Des Devel Ther. 2021;15. doi:10.2147/DDDT.S327378
  18. Ramaholimihaso T, Bouazzaoui F, Kaladjian A.  Front Psychiatry. 2020;11. doi:10.3389/fpsyt.2020.572533
  19. Afzal O, Dalhat MH, Altamimi ASA, et al. Molecules. 2022;27(21). doi:10.3390/molecules27217604
  20. Shamabadi A, Kafi F, Arab Bafrani M, Asadigandomani H, A. Basti F, Akhondzadeh S.  J Affect Disord. 2023;333. doi:10.1016/j.jad.2023.04.029
  21. Simpson T, Kure C, Stough C. Front Pharmacol. 2019;10. doi:10.3389/fphar.2019.00694
  22. Weichmann F, Rohdewald P.  Front Nutr. 2024;11. doi:10.3389/fnut.2024.1389374
Blog

Building Resilience: A Guide to Personalized Care for Stress

  • Oct 30, 2024
Pure Encapsulations Pro Blog

Building Resilience: A Guide to Personalized Care for Stress

Key Points

  1. Each patient's experience of stress is unique and shaped by multiple factors.
  2. A thorough understanding and personalized approach to the three stages of stress response is essential for supporting patients in recovering from stress and building resilience.
  3. A customized strategy not only addresses the diverse causes and symptoms of stress but also enhances patient engagement and outcomes.

Table of Contents:

  1. The Importance of a Personalized Approach to Stress Management
  2. Understanding Individual Differences in Stress Responses
  3. Building Resilience Against Stress
  4. The 3 Stages of Stress Adaptation: Expanding Your Knowledge
  5. Additional Resources

The Importance of a Personalized Approach to Stress Management

More than one-third of adults don’t know where to begin to manage their stress. For some, their healthcare practitioner may be the only person they talk to about their stress.[1] While stress is a universal experience with profound impacts on each patient’s overall health, its manifestation and effects are unique to everyone, necessitating a personalized approach . A customized strategy can address a wide range of stress symptoms and causes while also improving patient involvement and results.

Understanding Individual Differences in Stress Responses

Each patient's experience of stress is shaped by numerous factors including genetic predisposition, environmental factors, personal coping mechanisms and even the specific stressors themselves. A personalized approach allows the healthcare practitioner to address these distinctions, enabling more precise identification of stress triggers and the development of effective, individualized strategies.

Building Resilience Against Stress

The following infographic is a guide to providing comprehensive care for your patient that addresses the physiological and psychological mechanisms associated with the stress response, along with thorough assessment recommendations, diet, exercise, sleep adaptogenic and nutrient support. Infographic displaying 3 stages of adaptation and related assessments, and diet, exercise and supplement recommendations  

The Three Stages of Stress Adaptation: Expanding Your Knowledge

The 3 stages of stress adaptation are a framework that describes how the body responds to stress in three stages: alarm, resistance and exhaustion. A thorough understanding of the progression of these stages and how their presentation can vary between individuals is vital for supporting a patient’s response to stress and for promoting resilience to it.Explore our educational videos below to enhance your knowledge of the 3 stages of stress adaptation, the intricate relationship between stress, the hypothalamic-pituitary-adrenal (HPA) axis and the long-term effects of stress.

 

Additional Resources

Stress Management & Relaxation Protocol‡: developed with James Greenblatt, MD, a pioneer in the field of integrative medicine for mental health, this protocol offers nutrition and lifestyle recommendations to support stress management and relaxation.‡ Drug-Nutrient Interaction Checker: provides valuable information on potential interactions between your patients’ prescriptions, over-the-counter medications and nutritional supplements. PureInsight™: Our streamlined platform easily collects patient data and provides valuable, personalized recommendations to help achieve their unique health goals. Virtual Dispensary: our Pure Patient Direct program provides account holders FREE access to our virtual dispensary to help simplify patient sales and reduce in-office inventory.  

References

[1] American Psychological Association
Blog

The Role of Neurotransmitters in Attention, Focus and Behavior

  • Sep 24, 2024
Pure Encapsulations Pro Blog
 

The Role of Neurotransmitters in Attention, Focus and Behavior

 

Key Points:

  1. Approximately 6.76% of adults experience focus and attention related challenges.
  2. Neurotransmitters such as dopamine, norepinephrine, serotonin and acetylcholine play crucial roles in managing focus-related tasks.
  3. A balanced diet, regular exercise, and supplements can support neurotransmitter production and function. Consider food or supplements high in omega-3 fatty acids, vitamin D, magnesium and B vitamins for foundational support.‡
  4. Targeted supplements can support specific neurotransmitters that contribute to focus and attention: CogniPhos (acetylcholine), CurcumaSorb Mind (dopamine and serotonin) and DopaPlus (dopamine and norepinephrine).‡

Table of Contents:

  1. Introduction
  2. Key Neurotransmitters Involved in Focus
  3. Natural Ways to Support Neurotransmitter Balance
  4. Conclusion
  5. Resources

Introduction

For many, maintaining focus is a daily struggle that affects productivity and overall well-being. The prevalence of focus and attention issues is approximately 6.76%, or around roughly 366.33 million, adults globally. What causes these challenges with focus? One crucial factor is the brain’s neurotransmitters. Focus involves the ability to sustain attention on a particular task or goal, while ignoring distractions. It is essential for effective work, learning and daily functioning. Maintaining focus can be difficult for many people, leading to decreased productivity and increased stress. In this blog, we’ll explore how neurotransmitters impact our ability to focus, the role they play in managing focus-related tasks and provide some lifestyle solutions to support focus.

Key Neurotransmitters Involved in Focus

Dopamine: is essential for motivation, attention and reward processing. It helps regulate how we perceive and respond to stimuli, influencing our ability to stay focused on tasks. Low levels of dopamine can impair our ability to concentrate, stay organized, manage time effectively and may lead to challenges in maintaining attention on tasks.1 Norepinephrine: affects alertness and arousal. It helps the brain stay alert and responsive to stimuli, which is essential for maintaining focus. Norepinephrine has been shown to alter network activity in attention and working memory through arousal activation of the frontoparietal network, which is critical for sustained attention and alertness.2 Serotonin: influences mood, impulse control and overall cognitive function. It plays a role in managing emotional responses and maintaining a steady focus. Changes in serotonin levels can affect our emotional stability and our ability to maintain focus, leading to increased distractibility and impulsive actions.3 Acetylcholine: governs memory, learning, motivation and attention. Synthesized from choline, acetylcholine is the chief neurotransmitter of the parasympathetic nervous system and has a significant impact on muscle function, sleep, cognitive processes and mental performance.4 Fluctuations of acetylcholine can affect short-term memory, processing speed and word recall and can lead to learning difficulties and symptoms like brain fog.

Natural Ways to Support Neurotransmitter Balance‡

By understanding how neurotransmitters play a role in focus, attention and mood, you can better provide guidance on lifestyle changes that support neurotransmitter balance.

Diet and Nutrition

A balanced diet rich in essential nutrients can support neurotransmitter production and function. Foods high in omega-3 fatty acids and certain nutrients, such as vitamin D, magnesium and zinc, support the synthesis of neurotransmitters or assist their functioning.5 Very few research studies have investigated specific dietary patterns on focus or attention outcomes in randomized clinical trials. However, there is available evidence to provide broad recommendations, such as consuming nutrient-dense foods and limiting excessive added sugars as beneficial for attention problems. Mediterranean diets, rich in omega-3s and plant-based foods compared to Western diets, have also been associated with better mental health and mood.6

Exercise

Regular physical activity has been shown to boost levels of dopamine, norepinephrine and serotonin, which can enhance mood and improve concentration. In fact, in children who have problems with attention, exercise interventions improved overall executive function when participating in exercise.7 Additionally, there is a robust body of scientific evidence demonstrating positive outcomes on brain function in adults from long-term exercise. Several studies have shown positive effects of exercise on cognitive functioning, specifically on prefrontal cortex-dependent cognition. Even acute, short bursts of exercise have been shown to improve mood and emotional status.8  

Supplements

Various supplemental ingredients offer benefits to supporting neurotransmitter function.
  • CogniPhos: A blend of clinically researched Cognizen® citicoline, acetyl-L-carnitine, Sharp-PS® phosphatidylserine and cofactors. Cognizen® promotes daily cognitive performance and mental sharpness. 9,10‡
  • CurcumaSorb Mind: A curcumin and polyphenol blend to promote mood, memory and mental sharpness and support healthy levels of serotonin and dopamine. 11‡
  • DopaPlus: This formula provides the dopamine precursors L-tyrosine and L-DOPA (from Mucuna pruriens). DopaPlus supports dopamine production and maintains healthy reuptake for daily mental function and sharpness. 12, 13‡
  • Vitamin D + Magnesium: Vitamin D and Magnesium are both nutrients that play a role in the body’s nervous system. In a randomized-clinical trial, children supplemented with vitamin D and magnesium had a positive impact on and total difficulties compared to placebo after 8-weeks of supplementation.14‡
  • Fish oils:  are rich in omega-3 essential fatty acid. DHA, a fatty-acid in fish oil, is well recognized for its ability to support neural and cognitive function.  Epidemiological studies indicate that intake of DHA is associated with healthy cognitive function.15‡
  • Vitamin B6: A coenzyme involved in the synthesis of neurotransmitters needed for synaptic transmission (e.g., dopamine, serotonin, GABA).‡
  • Pycnogenol®: A highly researched maritime pine bark extract, which contains a unique mixture of proanthocyanidins and other polyphenols. Clinical trials have shown that pycnogenol supports parameters related to attention in both children and adults. 17-19‡
 
Intervention Dopamine Norepinephrine Serotonin Acetylcholine
CurcumaSorb Mind X X
DopaPlus X X
CogniPhos X
 

Conclusion

Understanding the relationship between neurotransmitters and focus offers valuable insights into managing focus-related challenges. By addressing neurotransmitter imbalances through lifestyle changes and supporting supplements, individuals can help improve their ability to concentrate and enhance their overall focus and attention.

Resources

Mood Protocol: Developed in collaboration with our scientific and medical advisors to support mood.‡ Drug-Nutrient Interactions Checker:  provides valuable information on potential interactions between your patients’ prescriptions, over-the-counter medications and nutritional supplements. PureInsight™: Our streamlined platform easily collects patient data and provides valuable recommendations to help patients achieve their health goals. Virtual Dispensary: Our Pure Patient Direct program provides account holders FREE access to our virtual dispensary to help simplify patient sales and reduce in-office inventory. You can also explore Pure Encapsulations® to find On-Demand Learning, Clinical Protocols, and other resources developed with our medical and scientific advisors.

References

  1. Kessi M, Duan H, Xiong J, C, et al. Front Mol Neurosci. 2022 Sep 21;15:925049. doi: 10.3389/fnmol.2022.925049.
  2. O'Donnell J, Zeppenfeld D, McConnell E, et al. Neurochem Res. 2012 Nov;37(11):2496-512. doi: 10.1007/s11064-012-0818-x. Epub 2012 Jun 21.
  3. Jones LA, Sun EW, Martin AM, Keating DJ. Int J Biochem Cell Biol. 2020 Aug;125:105776. doi: 10.1016/j.biocel.2020.105776. Epub 2020 May 29.
  4. Sam C, Bordoni B. Physiology, Acetylcholine. [Updated 2023 Apr 10]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK557825/
  5. Lange KW, Lange KM, Nakamura Y, et al. Curr Nutr Rep. 2023 Sep;12(3):383-394. doi: 10.1007/s13668-023-00487-8. Epub 2023 Jul 28.
  6. Firth J, Gangwisch JE, Borisini A, et al. BMJ. 2020 Jun 29;369:m2382. doi: 10.1136/bmj.m2382.
  7. Liang X, Li R, Wong SHS, et al. Int J Behav Nutr Phys Act. 2021 May 22;18(1):68. doi: 10.1186/s12966-021-01135-6.
  8. Basso JC, Suzuki WA. Brain Plast. 2017 Mar 28;2(2):127-152. doi: 10.3233/BPL-160040.
  9. McGlade E, et al. J Atten Disord. 2015 Jul 15.
  10. McGlade E, et al. Food and Nutrition Sciences, 2012, 3, 769-773.
  11. Bhutani MK, et al. Pharmacol Biochem Behav.2009 Mar;92(1):39-43.
  12. Katzenschlager R, et al. J Neurol NeurosurgPsychiatry2004;75:1672-1677.
  13. Ranjbar E, et al. Nutr Neurosci.2014 Feb;17(2):65-71.
  14. Hemamy M, Pahlavani N, Amanollahi A,et al. BMC Pediatr. 2021 Apr 17;21(1):178. doi: 10.1186/s12887-021-02631-1. Erratum in: BMC Pediatr. 2021 May 12;21(1):230. doi: 10.1186/s12887-021-02683-3.
  15. Jackson PA, et. al. Br J Nutr.2012 Apr;107(8):1093-8.
  16. Calderón-Ospina CA, Nava-Mesa MO. CNS Neurosci Ther. 2020 Jan;26(1):5-13. doi: 10.1111/cns.13207. Epub 2019 Sep 6.
  17. Belcaro G, Luzzi R, Dugall M, et al. J Neurosurg Sci. 2014 Dec;58(4):239-48. Epub 2014 Mar 28.
  18. Luzzi R, Belcaro G, Zulli C, et al. Panminerva Med. 2011 Sep;53(3 Suppl 1):75-82.
  19. Trebatická J, Kopasová S, Hradecná Z, et al. Eur Child Adolesc Psychiatry. 2006 Sep;15(6):329-35. doi: 10.1007/s00787-006-0538-3. Epub 2006 May 13.
 
Webinars

Magnesium: Forms, Functions and Evidence-Based Clinical Use

  • Nov 10, 2023
Pure Encapsulations Pro Blog


Watch the Webinar



View webinar library



 



Magnesium: Forms, Functions and Evidence-Based Clinical Use


Presented by: Kelly Heim, PhD*


Magnesium plays important roles in cardiovascular, neurocognitive, and mental health. Nearly half (48%) of Americans do not meet the estimated average requirement.1 Dietary supplements contain various forms of magnesium, which vary in bioavailability, cost and clinical uses. In this webinar, you will learn how to optimize magnesium effectively for specific health goals.‡





 



Learning objectives:



  • Understand key differences between 5 common forms of magnesium found in dietary supplements

  • Recognize common pitfalls and best practices when assessing magnesium status

  • Obtain up-to-date information on evidence-based uses, dosage, duration and monitoring to support cardiovascular, cognitive, and mental health.‡

  • Review contraindications and drug interactions


 




 


About the Speaker


Kelly C. Heim, Ph.D.* is Senior Consultant, Medical Affairs for Pure Encapsulations. He received his doctoral degree in pharmacology from Geisel School of Medicine at Dartmouth College and specializes in the pharmacology of natural compounds. Dr. Heim is a published author and illustrator of various studies, scholarly reviews and book chapters. He is also co-creator of PureGenomics®, a complimentary nutrigenomics service that delivers concise reports with diet, lifestyle and nutritional recommendations tailored to each patient’s unique genetic profile and specific needs.




*Dr. Heim is an employee of Pure Encapsulations.






 


Webinars

Building and Refurbishing Mitochondria For Cognitive, Muscular and Metabolic Health

  • Aug 2, 2023
Pure Encapsulations Pro Blog


Watch the Webinar



View webinar library



 



Building and Refurbishing Mitochondria For Cognitive, Muscular and Metabolic Health


Presented by: Kelly Heim, Ph.D.*


Mitochondria generate the energy required for almost all physiological functions within the body and are essential for healthy cognition, muscle function and metabolism. In this webinar, pharmacologist Kelly Heim, PhD* will review the current state of the science and its clinical implications in neurocognitive, muscular and metabolic health.





 



Learning Objectives:



  • Learn how healthy mitochondria contribute to brain, muscle and metabolic health

  • Discover which types of exercise and dietary habits can enhance mitochondrial quality and quantity

  • Review current evidence-based indications and condition-specific interventions that support mitochondrial health



 




 


About the Speaker


Kelly C. Heim, Ph.D.* is Senior Scientific Director of Pharmacology & Genomics for Pure Encapsulations. He received his doctoral degree in pharmacology from Geisel School of Medicine at Dartmouth College and specializes in the pharmacology of natural compounds. Dr. Heim is a published author and illustrator of various studies, scholarly reviews and book chapters. He offers complimentary learning resources on the basics of clinical pharmacology of natural products via his website, IntegrativePharmacology.com.




*Dr. Kelly Heim is an employee of Atrium Innovations Inc.






 


Blog

Nutritional and Lifestyle Interventions for Positive Mood: A Quick Guide for Providers

  • May 17, 2023
Pure Encapsulations Pro Blog






Two women outdoors in athletic wear, smiling in the sunlight




Nutritional and Lifestyle Interventions for Positive Mood: A Quick Guide for Providers






“How are you feeling?” It’s a question we’re asked almost every day, and according to the statistics, many of us are not feeling so well. In the United States more than 50% of Americans will need support for their mental health at some point in their lifetime.1, 2 The good news is that there are many lifestyle factors we can incorporate in our daily lives to support our mood:



1. Reduce and manage stress. Stress is impossible to completely remove from our lives, but we can manage it by setting firm boundaries, making time for your needs, asking for help where you need it and engaging in rituals such as journaling, meditation and breathing techniques.



2. Exercise and movement. Moving your body has many mood enhancing benefits including reduced stress hormones, increased endorphins and improved sleep and digestion.3  You don't have to only go to a gym — dancing, walking and playing with your kids all count too. The key to consistent movement is making sure you enjoy it.



3. Ensure adequate sleep. Sleep is truly the foundation of health because it’s during sleep that our body clears out the debris, rebuilds and heals. A 2021 study found a link between sleep and mood through the glymphatic system which is highly active during sleep and clears metabolic waste out of the brain through fluid exchange.4



4. Exposure to sunlight and nature. Daily sunlight helps regulate our circadian rhythms which supports sleep and boosts mood by increasing serotonin. It’s also a source of vitamin D. Getting out into nature further reinforces that serotonin boost.5‡



5. Connection and community. Connection is a fundamental human need and in our technological age we’re getting much less. Having a supportive community where you feel like you belong can reduce the incidence of anxiety and depression.6 Engage in recreational sports, volunteering and other group activities to enhance your mood.



6. Consume a healthy diet. A diet focused on whole foods that’s lower in sugar, and higher in protein, healthy fats and complex carbohydrates provides the necessary amino acids, fats and nutrients that support the creation of mood supporting hormones and neurotransmitters.



7. Supplement as needed. Sometimes we need extra support, and this is where supplements can play a significant role in helping the body obtain the necessary nutrients to support mood. Taking a synergistic approach to supplementing for mood tends to yield the best results since there are many contributing factors. Below are some potential options:



  • Multivitamin: A high quality multivitamin delivers many of the nutrients needed to support neurotransmitter synthesis, including zinc and B vitamins.‡

  • Omega 3 Fatty Acids: Omega 3 fatty acids are called essential fatty acids because your body needs them but can’t produce them. In observational and epidemiological studies, higher plasma levels of EPA have been associated with healthy mood. 7, 8‡

  • Magnesium: Magnesium has many systemic benefits. In a cross-sectional study involving 210 elderly individuals, optimal magnesium intake was associated with positive mood.9‡

  • Probiotics: Gut health plays an important role in mental health. Probiotics encourage healthy gut bacterial ecology and intestinal integrity.10, 11‡.

  • Curcumin: The antioxidant and immune-modulating properties of curcumin have been implicated in mood, relaxation and neuronal health.12, 13

  • B Vitamins: Folate, vitamin B6 and vitamin B12 promote methylation, nerve support and cellular energy production. Folate plays important roles in emotional well-being.‡

  • Rhodiola: Rhodiola is an adaptogenic herb that has been used for hundreds of years to help lessen mental and physical stress.16, 17, 18‡

  • L-theanine: L-theanine is the active component of green tea that promotes relaxation without causing drowsiness.19‡


Supporting mood and stress resilience is critical as a foundation for health. It is essential that clinicians assess stress levels as part of the bigger picture so that appropriate measures can be taken.



Pure Encapsulations’ Mood Protocol and mood support formulas provide research-backed solutions for your patients’ needs.‡


REFERENCES



  1. Kessler RC, et al. World Psych. 2007;6(3):168-176.

  2. Key Substance Use and Mental Health Indicators in the United States: Results from the 2015 National Survey on Drug Use and Health. Rockville, MD: Center for Behavioral Health Statistics and Quality. 2016.

  3. Cooney, GM, Dwan K, Mead G. JAMA. 2014 Jun 18;311(23):2432-3

  4. Yan T, et al. Front Psychiatry. 2021; 12: 658340.

  5. Bum-Jin Park, et al. Int J Environ Res Public Health. 2020 Jun; 17(12): 4348.

  6. Schaefer S, et al. PLoS One. 2013; 8(11): e80329.

  7. Féart C, et. al. Am J Clin Nutr. 2008 May;87(5):1156-62.

  8. Samieri C, et. al. Am J Clin Nutr. 2008 Sep;88(3):714-21.

  9. Barragán-Rodríguez L, et al. Magnes Res. 2008 Dec;21(4):218-23.

  10. Arseneault-Bréard J, et al. Br J Nutr. 2012 Jun;107(12):1793-9.

  11. Rao AV, et al. Gut Patho. 2009 Mar 19;1(1):6.

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  13. Bhutani MK, et al. Pharmacol Biochem Behav. 2009 Mar;92(1):39-43.

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Webinars

Integrative Care for Calm and Relaxation

  • Jul 13, 2022
Pure Encapsulations Pro Blog


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Integrative Care for Calm & Relaxation


Presented by: James Greenblatt, MD+


In this webinar, integrative psychiatrist and mental health expert Dr. James Greenblatt will explore key considerations for supporting calm, relaxation and the mental health of patients. 





 



Learning Objectives:



  • Learn why amino acids availability and digestion are so important for mental health.‡

  • Find out how vitamin D levels can affect serotonin synthesis.‡

  • Discover which interventions Dr. Greenblatt commonly uses to support calm and relaxation.‡

  • Review the importance of lifestyle factors and “Vitamin R”


 




 


About the Panelist


James Greenblatt, MD+ James Greenblatt integrates both medical and complementary therapies to support mental health and well-being. In addition to serving as the chief medical officer and vice president of medical services at Walden Behavioral Care in Waltham, Massachusetts, Dr. Greenblatt is a clinical faculty member at Tufts University School of Medicine. Dr. Greenblatt also helped co-develop the PureSYNAPSE™ protocols.


+ Our Medical Advisors are retained consultants for Pure Encapsulations.






 


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A Functional Approach to Brain Health

  • Jun 15, 2022
Pure Encapsulations Pro Blog


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A Functional Approach to Brain Health


Presented by: Shelena Lalji, MD, FACOG+


Brain health was ranked as one of the top 5 areas of interest by practitioners like you. Because there are many different aspects of brain health, practitioners and patients are often left with more questions than answers to this complex and confusing topic. In this webinar, Dr. Shel shares her approach using functional medicine techniques and rigorous testing to help understand and approach patients.





 



Learning Objectives:



  • Understand the complexities shared between.

  • Learn how to assess and test for brain health.

  • Discover functional techniques which can help address root causes as well as mind/body impacts


 




 


About the Panelist


Shelena Lalji, MD, FACOG+ Known as “Dr. Shel,” Shelena Lalji is the founder and medical director of the Dr. Shel Wellness & Aesthetic Center in Sugar Land, Texas. Dr. Shel is a board-certified obstetrician and gynecologist. She is a national trainer and an international speaker on several integrative/functional medicine topics and on advanced aesthetic treatments. Dr. Shel is a published author and an advocate for her patients and her local community, as well as a firm believer in addressing the root causes of her patients' health and well-being.


+ Our Medical Advisors are retained consultants for Pure Encapsulations.






 


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Clarity with COMT: Integrating Mental Health Support & Nutritional Genomics

  • Nov 12, 2020
Pure Encapsulations Pro Blog

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Clarity with COMT: Integrating Mental Health Support & Nutritional Genomics


Presented by: Peter Bongiorno, N.D. La.C.
Thursday, November 12, 2020

Functional medicine is the vanguard of understanding how the underlying drivers of mental health can have clear connections to a patient’s genetics. Dr. Bongiorno will guide you through his functional approach to using nutritional genomics in practice by diving deeper into one of the genes most involved in mental health, Catechol-O-methyltransferase (COMT).








Learning Objectives:

  • Discover why Dr. Bongiorno looks to COMT as his first step in assessing a patient’s genetic report

  • Understand the dynamic and important role of COMT in mental health

  • Learn how to assess COMT status in your patients, and how to support them using Dr. Bongiorno’s recommendations







About the Panelists


Peter Bongiorno, N.D. La.C.+ is president of the NY Association of Naturopathic Physicians and co-medical director of Inner Source Health in New York with his wife, Dr. Pina LoGiudice. In 2010, he authored the first comprehensive textbook designed to teach physicians how to use natural medicine for mood support. Dr. Bongiorno has been regularly interviewed on national television and radio as a natural medicine expert and writes articles for national media, including Psychology Today.

+ Our Medical Advisors are retained consultants for Pure Encapsulations.


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