NR Longevity™

Verifiable Science

NR Longevity is specially designed to target biological processes that decline with age, such as the body’s natural ability to make energy, build new mitochondria and protect cells from oxidative stress.¹ Nicotinamide riboside (NR), resveratrol and sulforaphane promote healthy aging by replenishing NAD+, enhancing mitochondrial function and providing antioxidant support, respectively. Nicotinamide riboside (NR) is a form of vitamin B₃ that acts as a precursor of nicotinamide adenine dinucleotide (NAD+), which plays a critical role in cellular energy production.^2-4 NAD+ activates enzymes in the sirtuin family, considered to be master switches of metabolism and regulators of aging. Notably, NAD+ activates SIRT1, an epigenetic switch that regulates metabolism and supports mitochondrial biogenesis, cellular energy production and cellular longevity.^5,6 Higher NAD+ levels are associated with healthy mitochondrial function.^7,8 Conversely, cellular NAD+ levels decline with age, and can decrease by up to 50% over the adult lifespan.^7-11 Supplementing with NR enhances NAD+ levels, supporting the function of NAD+ dependent enzymes that maintain cellular energy production and repair. NR has been clinically shown to increase NAD+ levels in as little as 2 weeks.² Resveratrol and sulforaphane promote longevity in model organisms.^12-14 Both compounds enhance cellular antioxidant defenses, helping to protect cells against oxidative stress that increases with age and contributes to age-related cellular decline.^1,15-18 Resveratrol activates the AMPK/SIRT1/PGC-1alpha axis, a pathway that enhances mitochondrial function and supports normal cellular repair while sulforaphane activates Nrf2, a genomic switch that stimulates expression of genes involved in antioxidant defense, cellular protection and mitochondrial biogenesis.^12,13,15-20 Nrf2 is a transcription factor that supports robust, long-lasting expression of numerous genes responsible for phase II detoxification and protection against oxidative stress. Among these genes are glutathione peroxidase, superoxide dismutase and various phase II enzymes, such as glutathione sulfotransferases. Nrf2 also supports expression of glutathione glutamylcysteinyl ligase, which is responsible for a critical step in the biosynthesis of glutathione, a vital component of cellular antioxidant and detoxification systems.^{15-18 ‡}