Folate 5,000 60's

Universally metabolized form of folate

Retail Price



Pure Encapsulations® products are formulated using high-quality, pure ingredients, FREE FROM unnecessary additives and many common allergens including:

Wheat, Soy, Dairy, Eggs
Artificial Colors & Sweeteners
Coatings & Shellacs
Tree Nuts, Peanuts & Sesame
Unnecessary Binders, Fillers & Preservatives
Magnesium Stearate
Trans Fat & Hydrogenated Oils

Benefits & Features

  • Provides the active form of folate, directly bioavailable without metabolic activation
  • Provides cardiovascular, cellular and neural protection
  • 5,000 mcg of activated folate per capsule
  • Contains Metafolin® , the universally metabolized and biologically active form of folate
  • Made with high-quality, vegan ingredients backed by verifiable science


  • Ages 18 and up
  • Cardiovascular, cellular and neuronal support

Suggested Use

As a dietary supplement, take 1 capsule daily, with a meal, or as directed by a health professional.

Science & Research

Verifiable Science

Folate 5,000 provides 5,000 mcg of folate as 5-methyltetrahydrofolate (5-MTHF), the universally metabolized and biologically active form of folate. 1,2 Genetic variations affecting activation and metabolism of supplemental folic acid are highly prevalent.3 Through bypassing several enzymatic activation steps catalyzed by DHFR (dihydrofolate reductase) and MTHFR (methylenetetrahydrofolate reductase), 5-MTHF is directly usable by the body and provides all of the benefits of folic acid regardless of functional or genetic variations in these enzymes.4 At the molecular level, the main function of folate is to donate methyl groups in key biochemical reactions occurring in blood cells, neurons, the vasculature and many other tissues.5,6 In addition, folate promotes the production of healthy DNA.7‡


  1. Prinz-Langenohl R, et al. Br J Pharmacol. 2009 Dec; 158(8): 2014–2021.
  2. Lamers Y, et al. Am J Clin Nutr. 2006 Jul;84(1):156-61.
  3. Yang Q, et al. Am J Clin Nutr. 2012;95(5):1245-1253.
  4. Seremak-Mrozikiewicz A. Ginekol Pol. 2013 Jul;84(7):641-6.
  5. Terry MB, et al. Epigenetics. 2011. 6(7); 828-37.
  6. Stanhewicz AE, et al. Clin Sci (Lond). 2015 Jul;129(2):159-67.
  7. Duthie SJ. J Inherit Metab Dis. 2011 Feb;34(1):101-9.

Additional Information


Use only under medical supervision. If you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.


Store in a cool, dry place.


  • Metafolin®, L-5-methyltetrahydrofolate (L-5-MTHF) is synthetic
  • Hypoallergenic plant fiber is derived from pine cellulose

Free From

Gluten Free GMO Free Vegan Vegetarian